Alpha-melanocyte stimulating hormone (alpha-MSH) is a critically important regulatory neuropeptide. It is produced in the hypothalamus, an area of the brain important for hormonal control of the body, and where the nervous system meets the endocrine system. Small amounts are probably also produced elsewhere in the brainstem. (1) What does a-MSH do: Helps regulate other hormones (cortisol/ACTH, ADH, [...]